Biografia e Studi Scientifici sull'acqua ionizzata (2)
Lesioni da Ischemia e Riperfusione:
298.Cai, J., et al., Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett, 2008. 441(2): p. 167-172.
299.Cai, J.M., et al., Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res, 2009. 1256: p. 129-137.
300.Chen, H., et al., The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. Journal of Surgical Research, 2011. 167(2): p. 316-22.
301.Fukuda, K., et al., Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun, 2007. 361(3): p. 670-674.
302.Ge, P., et al., Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress. Neurological Research, 2012. 34(2): p. 187-94.
303.Han, L., et al., Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins. Brain Res, 2015.
304.Hayashida, K., et al., Inhalation of hydrogen gas protects the heart from ischemic reperfusion injury. Journal of the American College of Cardiology, 2008. 51(10): p. A375-A375.
305.Hayashida, K., et al., Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Journal of Cardiac Failure, 2008. 14(7): p. S168-S168.
306.Huang, Y., et al., Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits. Brain Research, 2011. 1378: p. 125-136.
307.Huang, T., et al., Hydrogen-rich saline attenuates ischemia-reperfusion injury in skeletal muscle. J Surg Res, 2015. 194(2): p. 471-80.
308.Ji, Q., et al., The effect of hydrogen-rich saline on the brain of rats with transient ischemia. Journal of Surgical Research, 2011. 168(1): p. e95-e101.
309.Jiang, D., et al., Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats. J Urol, 2012. 187(6): p. 2249-53.
310.Kawamura, T., et al., Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury in Rats. Transplantation, 2010. 90(12): p. 1344-1351.
311.Kuroki, C., et al., Neuroprotective Effects of Hydrogen Gas on Brain in Ischemia-Reperfusion Model: A P-31-Nmr Study. Journal of Physiological Sciences, 2009. 59: p. 371-371.
312.Kuroki, C., et al., Neuroprotective effects of hydrogen gas on brain in hypoxic stress model and ischemia-reperfusion model: A P-31 NMR study. Neuroscience Research, 2008. 61: p. S274-S274.
313.Lee, J.W., et al., Inhaled hydrogen gas therapy for prevention of testicular ischemia/reperfusion injury in rats. Journal of Pediatric Surgery, 2012. 47(4): p. 736-742.
314.Li, H., et al., Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits. Journal of Surgical Research, 2012. 174(1): p. e11-6.
315.Li, J., et al., Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines. Brain Research, 2012. 1486: p. 103-11.
316.Liu, Y., et al., Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model. Medical Gas Research, 2011. 1(1): p. 15.
317.Liu, Y.Q., et al., Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. Reconstructive & Aesthetic Surgery, 2015.
318.Liu, R., et al., Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats. Exp Biol Med (Maywood), 2015.
319.Luo, Z.L., et al., Hydrogen-Rich Saline Protects against Ischemia/Reperfusion Injury in Grafts after Pancreas Transplantations by Reducing Oxidative Stress in Rats. Mediators Inflamm, 2015. 2015: p. 281985.
320.Mao, Y.F., et al., Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun, 2009. 381(4): p. 602-5.
321.Matchett, G.A., et al., Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models. Brain Research, 2009. 1259: p. 90-7.
322.Nagatani, K., et al., Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia. Shock 37(6):645-652, 2012 Reply. Shock, 2012. 38(4): p. 444-445.
323.Nagatani, K., et al., Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia. Shock, 2012. 37(6): p. 645-652.
324.Nakao, A., et al., Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2010. 29(5): p. 544-53.
325.Noda, K., et al., A novel method of preserving cardiac grafts using a hydrogen-rich water bath. Journal of Heart and Lung Transplantation, 2013. 32(2): p. 241-50.
326.Shingu, C., et al., Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury. Journal of Anesthesia, 2010. 24(4): p. 569-574.
327.Sun, Q., et al., Hydrogen-Rich Saline Protects Myocardium Against Ischemia/Reperfusion Injury in Rats. Experimental Biology and Medicine, 2009. 234(10): p. 1212-1219.
328.Tan, M., et al., Hydrogen as additive of HTK solution fortifies myocardial preservation in grafts with prolonged cold ischemia. International Journal of Cardiology, 2013. 167(2): p. 383-90.
329.Wang, F., et al., Hydrogen-Rich Saline Protects Against Renal Ischemia/Reperfusion Injury in Rats. Journal of Surgical Research, 2011. 167(2): p. e339-44.
330.Yonamine, R., et al., Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice. Anesthesiology, 2013. 118(1): p. 105-13.
331.Zhang, J., et al., Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia (Shock 37(6), 645-652, 2012). Shock, 2012. 38(4): p. 444; author reply 444-5.
332.Zhang, Y., et al., Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. International Journal of Cardiology, 2011. 148(1): p. 91-5.
333.Zhao, L., et al., Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap. J Zhejiang Univ Sci B, 2013. 14(5): p. 382-91.
334.Zheng, X., et al., Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats. Free Radic Res, 2009. 43(5): p. 478-84.
335.Zhou, H., et al., Hydrogen inhalation decreases lung graft injury in brain-dead donor rats. Journal of Heart and Lung Transplantation, 2013. 32(2): p. 251-8.
336.Zhou, L., et al., Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits. Brain Research, 2013. 1517: p. 150-60.
337.Zhu, W.J., et al., Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats. Nephrology, Dialysis, Transplantation, 2011. 26(7): p. 2112-8.
338.Abe, T., et al., Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury. Transplantation, 2012. 94(1): p. 14-21.
339.Cardinal, J.S., et al., Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney International, 2010. 77(2): p. 101-9.
340.Homma, K., et al., Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats. Nephron Exp Nephrol, 2015.
341.Gu, H., et al., Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats. J Surg Res, 2014. 188(1): p. 243-9.
342.Katakura, M., et al., Hydrogen-rich water inhibits glucose and alpha,beta -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney. Medical Gas Research, 2012. 2(1): p. 18.
343.Kato, S., et al., Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity. J Nanosci Nanotechnol, 2012. 12(5): p. 4019-27.
344.Kitamura, A., et al., Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. British Journal of Radiology, 2010. 83(990): p. 509-514.
345.Liu, W., et al., A novel fluid resuscitation protocol: provide more protection on acute kidney injury during septic shock in rats. Int J Clin Exp Med, 2014. 7(4): p. 919-26.
346.Matsushita, T., et al., Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging. Magn Reson Med Sci, 2011. 10(3): p. 169-76.
347.Nakayama, M., et al., Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water. Hemodial Int, 2007. 11(3): p. 322-7.
348.Ohaski, Y., et al., Electrolyzed water reduces urinary protein excretion in the streptozotocin induced diabetic Dahl salt sensitive rats. The FASEB Journal, 2008. 22: p. 947.17.
349.Terawaki, H., et al., Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients. Hemodial Int, 2014. 18(2): p. 459-66.
350.Terawaki, H., et al., Successful treatment of encapsulating peritoneal sclerosis by hemodialysis and peritoneal lavage using dialysate containing dissolved hydrogen. Perit Dial Int, 2015. 35(1): p. 107-12.
351.Xin, H.G., et al., Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats. Mol Cell Biochem, 2014. 392(1-2): p. 117-24.
352.Zhu, W.J., et al., Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water. Med Gas Res, 2013. 3(1): p. 26.
353.Gharib, B., et al., Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. C R Acad Sci III, 2001. 324(8): p. 719-724.
354.Itoh, T., et al., Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun, 2009. 389(4): p. 651-6.
355.Kajiya, M., et al., Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun, 2009. 386(2): p. 316-21.
356.Koyama, Y., et al., Effects of Oral Intake of Hydrogen Water on Liver Fibrogenesis in Mice. Hepatol Res, 2013.
357.Koyama, Y., et al., Effects of oral intake of hydrogen water on liver fibrogenesis in mice. Hepatol Res, 2014. 44(6): p. 663-677.
358.Lee, P.C., et al., Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen-rich saline and N-acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats. Hepatol Res, 2014.
359.Liu, G.D., et al., Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells. Int J Ophthalmol, 2013. 6(3): p. 280-5.
360.Liu, Q., et al., Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver International, 2010. 30(7): p. 958-968.
361.Liu, Y., et al., Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release. BMC Gastroenterol, 2014. 14: p. 12.
362.Matsuno, N., et al., Beneficial effects of hydrogen gas on porcine liver reperfusion injury with use of total vascular exclusion and active venous bypass. Transplant Proc, 2014. 46(4): p. 1104-6.
363.Nishimura, N., et al., Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia-reperfusion injury in rats. Br J Nutr, 2012. 107(4): p. 485-92.
364.Park, S.K., et al., Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats. Biomed Res, 2009. 30(5): p. 263-9.
365.Shen, M.H., et al., Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning. Medical Hypotheses, 2010. 75(2): p. 235-237.
366.Sun, H., et al., The protective role of hydrogen-rich saline in experimental liver injury in mice. Journal of Hepatology, 2011. 54(3): p. 471-80.
367.Tan, Y.C., et al., Hydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats. Clin Res Hepatol Gastroenterol, 2014. 38(3): p. 337-45.
568.Tange, Y., S. Takesawa, and S. Yoshitake, Dialysate with high dissolved hydrogen facilitates dissociation of indoxyl sulfate from albumin. Nephrourol Mon, 2015. 7(2): p. e26847.
369.Tsai, C.F., et al., Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol, 2009. 47(8): p. 2031-6.
370.Wang, W., et al., Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning. Journal of Emergency Medicine, 2013. 44(1): p. 107-15.
371.Xiang, L., et al., Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine. World Journal of Gastroenterology, 2012. 18(37): p. 5197-5204.
372.Xu, X.F. and J. Zhang, Saturated hydrogen saline attenuates endotoxin-induced acute liver dysfunction in rats. Physiol Res, 2013. 62(4): p. 395-403.
373.Zhang, C.B., et al., Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB signaling pathway. Experimental and Therapeutic Medicine, 2015. 9(6): p. 2114-2120.
374.Zhang, J.Y., et al., Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice. World J Gastroenterol, 2015. 21(14): p. 4195-209.
375.Du, Z., et al., Protective effects of hydrogen-rich saline in uncontrolled hemorrhagic shock. Journal of Surgical Research, 2014. In press.
376.Fang, Y., et al., Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. Journal of Burn Care and Research, 2011. 32(3): p. e82-91.
377.Haam, S., et al., The effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after cardiac deathdagger. Eur J Cardiothorac Surg, 2015.
378.Huang, C.S., et al., Hydrogen inhalation ameliorates ventilator-induced lung injury. Critical Care, 2010. 14(6): p. R234.
379.Huang, C.S., et al., Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochemical and Biophysical Research Communications, 2011. 408(2): p. 253-8.
380.Kawamura, T., et al., Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol, 2013. 304(10): p. L646-56.
381.Li, S., et al., Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice. J Assist Reprod Genet, 2014. 31(1): p. 109-14.
382.Liang, C., et al., [Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide- induced acute lung injury]. Nan Fang Yi Ke Da Xue Xue Bao, 2012. 32(8): p. 1211-3.
383.Liu, S., et al., Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. Journal of Biomedicine & Biotechnology, 2011. 2011: p. 305086.
384.Liu, R., et al., Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats. Exp Biol Med (Maywood), 2015.
385.Liu, S.L., et al., Hydrogen Therapy may be a Novel and Effective Treatment for COPD. Front Pharmacol, 2011. 2: p. 19.
386.Liu, H., et al., Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury. Shock, 2015. 43(5): p. 504-11.
387.Liu, W., et al., Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. World J Gastroenterol, 2013. 19(4): p. 492-502.
388.Ning, Y., et al., Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. PLoS One, 2013. 8(12): p. e83429.
389.Noda, K., et al., Hydrogen Preconditioning During Ex Vivo Lung Perfusion Improves the Quality of Lung Grafts in Rats. Transplantation 2014. ??
390.Qiu, X., et al., Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol, 2011. 11(12): p. 2130-7.
391.Qiu, X.C., et al., [Effect of hydrogen-rich saline on blood pressure and antioxidant ability of lung tissue in scalded rats following delayed resuscitation]. Zhonghua Shao Shang Za Zhi, 2010. 26(6): p. 435-8.
392.Sato, C., et al., Effects of hydrogen water on paraquat-induced pulmonary fibrosis in mice. The Kitasato medical journal 2015. 45(1): p. 9-16.
393.Shi, J., et al., Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats. Heart Lung Circ, 2012. 21(9): p. 556-63.
394.Sun, Q.A., et al., Hydrogen-Rich Saline Provides Protection Against Hyperoxic Lung Injury. Journal of Surgical Research, 2011. 165(1): p. E43-E49.
395.Tanaka, Y., et al., Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun, 2012. 425(4): p. 873-9.
396.Terasaki, Y., et al., Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. American Journal of Physiology – Lung Cellular and Molecular Physiology, 2011. 301(4): p. L415-26.
397.Tomofuji, T., et al., Effects of hydrogen-rich water on aging periodontal tissues in rats. Sci Rep, 2014. 4: p. 5534.
398.Xiao, M., et al., Hydrogen-rich saline reduces airway remodeling via inactivation of NF-kappaB in a murine model of asthma. Eur Rev Med Pharmacol Sci, 2013. 17(8): p. 1033-43.
399.Xie, K., et al., Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock, 2012. 37(5): p. 548-55.
400.Zhai, Y., et al., Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. Exp Mol Pathol, 2015. 98(2): p. 268-276.
401.Zhang, J., et al., Effect of hydrogen-rich water on acute peritonitis of rat models. Int Immunopharmacol, 2014. 21(1): p. 94-101.
402.Zheng, J., et al., Saturated hydrogen saline protects the lung against oxygen toxicity. Undersea & Hyperbaric Medicine, 2010. 37(3): p. 185-192.
402.Abe, M., et al., Suppressive Effect of ERW on Lipid Peroxidation and Plasma Triglyceride Level, in Animal Cell Technology: Basic & Applied Aspects. S. Netherlands, Editor. 2010. p. 315-321.
403.Amitani, H., et al., Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle. PLoS One, 2013. 8(1).
404.Baek, D.-H., Antibacterial Activity of Hydrogen-rich Water Against Oral Bacteria. 2013.
405.Chao, Y.C. and M.T. Chiang, Effect of alkaline reduced water on erythrocyte oxidative status and plasma lipids of spontaneously hypertensive rats. Taiwanese Journal of Agricultural Chemistry and Food Science, 2009. 47(2): p. 71-72.
406.Chen, C.H., et al., Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation in a Focal Ischemia Rat Model. Neuroscience, 2010. 169(1): p. 402-414.
407.Chen, Y., et al., Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways. International Journal of Molecular Medicine, 2013. 31(3): p. 597-606.
408.Chiasson, J.L., et al., Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA, 2003. 290(4): p. 486-94.
409.Dan, J., et al., Effect of mineral induced alkaline reduced water on sprague-dawley rats fed on a high fat diet. J. Exp. Biomed. Sci., 2006. 12: p. 1-7.
410.Ekuni, D., et al., Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model. Arch Oral Biol, 2012. 57(12): p. 1615-22.
411.Fan, M., et al., Protective Effects of Hydrogen-Rich Saline Against Erectile Dysfunction in a Streptozotocin Induced Diabetic Rat Model. J Urol, 2012.
412.Fan, M., et al., Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model. Journal of Urology, 2013. 190(1): p. 350-6.
413.GU, H.Y., et al., Anti-oxidation Effect and Anti Type 2 Diabetic Effect in Active Hydrogen Water. Medicine and Biology, 2006. 150(11): p. 384-392.
415.Hamaskai, T., et al., The suppressive effect of electrolyzed reduced water on lipid peroxidation. Animal Cell Technology: Basic & Applied Aspects, 2003. 13: p. 381-385.
416.Hashimoto, M., et al., Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat model. Medical Gas Research, 2011. 1(1): p. 26.
417.He, B., et al., Protection of oral hydrogen water as an antioxidant on pulmonary hypertension. Mol Biol Rep, 2013. 40(9): p. 5513-21.
418.Ignacio, R.M., et al., Anti-obesity effect of alkaline reduced water in high fat-fed obese mice. Biol Pharm Bull, 2013. 36(7): p. 1052-9.
419.Iio, A., et al., Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells. Medical Gas Research, 2013. 3(1): p. 6.
420.Jiang, H., et al., Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits advanced glycation end product-induced apoptosis. Int J Mol Med, 2013. 31(6): p. 1381-7.
421.Jin, D., et al., Anti-diabetic effect of alkaline-reduced water on OLETF rats. Biosci Biotechnol Biochem, 2006. 70(1): p. 31-7.
422.Kamimura, N., et al., Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice. Obesity, 2011.
423.Kawai, D., et al., Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Hepatology, 2012. 56(3): p. 912-21.
424.Kim, H.-W., Alkaline Reduced Water produced by UMQ showed Anti-cancer and Anti-diabetic effect. published online at http://www.korea-water.com/images/e_q.pdf 2004.
425.Kim, M.J. and H.K. Kim, Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice. Life Sci, 2006. 79(24): p. 2288-92.
426.Kim, M.J., et al., Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice. Biol Pharm Bull, 2007. 30(2): p. 234-6.
427.Li, Y., et al., Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species. Cytotechnology, 2002. 40(1-3): p. 139-49.
428.Li, Y.-P., Teruya, K., Katakura, Y., Kabayama, S., Otsubo, K.,Morisawa, S., et al, Effect of reduced water on the apoptotic cell death triggered by oxidative stress in pancreatic b HIT-T15 cell. Animal cell technology meets genomics, 2005: p. 121-124.
429.Li, Y., et al., Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology, 2011. 63(2): p. 119-31.
430.Nakai, Y., et al., Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water. Bioscience, Biotechnology, and Biochemistry, 2011. 75(4): p. 774-6.
431.Nelson, D., et al., Effect of electrolyzed water intake on lifespan of autoimmune disease prone mice. Faseb Journal, 1998. 12(5): p. A794-A794.
432.Nishioka, S., et al., Effect of hydrogen gas inhalation on lipid metabolism and left ventricular remodeling induced by intermittent hypoxia in mice. European Heart Journal, 2012. 33: p. 794-794.
433.Oda, M., et al., Electrolyzed and natural reduced water exhibit insulin-like activity on glucose uptake into muscle cells and adipocytes. Animal Cell Technology: Products from Cells, Cells as Products, 2000: p. 425-427.
434.Ohsawa, I., et al., Consumption of hydrogen water prevents atherosclerosis in apoliporotein E knockout mice. Biochem Biophys Res Commun, 2008. 377(4): p. 1195-8.
435.Shirahata, S., Anti-oxidative water improves diabetes. 2001.
436.Shirahata, S., et al., Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles. BMC Proc, 2011. 5 Suppl 8: p. P18.
437.Song, G., et al., H2 inhibits TNF-alpha-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor kappaB activation in endothelial cells. Biotechnology Letters, 2011. 33(9): p. 1715-22.
438.Song, G., et al., Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice. Atherosclerosis, 2012. 221(1): p. 55-65.
439.Tanabe, H., et al., Suppressive Effect of High Hydrogen Generating High Amylose Cornstarch on Subacute Hepatic Ischemia-reperfusion Injury in Rats. Biosci Microbiota Food Health, 2012. 31(4): p. 103-8.
440.Wang, Y., et al., Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. Respir Res, 2011. 12: p. 26.
441.Wang, Q.J., et al., Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress. Chin Med J (Engl), 2012. 125(9): p. 1633-7.
442.Yang, X., et al., Protective effects of hydrogen-rich saline in preeclampsia rat model. Placenta, 2011. 32(9): p. 681-6.
443.Yeunhwa GU, K.O., Taigo FUj, Yuka ITOKAWA, et al., Anti Type 2 Diabetic Effect and Anti-oxidation Effect in Active Hydrogen Water Administration KK-Ay Mice. Medicine and Biology, 2006. 150(11): p. 384-392.
444.Yu, P., et al., Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. Biochemical and Biophysical Research Communications, 2011. 409(2): p. 350-5.
445.Yu, Y.S. and H. Zheng, Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. Mol Cell Biochem, 2012. 365(1-2): p. 233-42.
446.Zheng, H. and Y.S. Yu, Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats. Biochemical Pharmacology, 2012. 83(9): p. 1269-77.
447.Zong, C., et al., Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters. Metabolism, 2012. 61(6): p. 794-800.
448.Yokoyama, J.-m.K.a.K., Effects of alkaline ionized water on spontaneously diabetic GK-rats fed sucrose. Korea. J. of Lab. Anim Sa, 1997. 13(2): p. 187-190.
449.Chen, Y., et al., H Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation, 2015.
450.Chen, Q., et al., Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci, 2013. 40(6): p. 857-63.
451.Ge, Y., et al., Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of Activation of Spinal Astrocytes and Microglia in Rats. PLoS One, 2014. 9(5): p. e97436.
452.Guan, Z., et al., Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells. Arch Gynecol Obstet, 2015.
453.Kawaguchi, M., et al., Molecular hydrogen attenuates neuropathic pain in mice. PLoS One, 2014. 9(6): p. e100352.
454.Koseki, S. and K. Itoh, Fundamental properties of electrolyzed water. Journal of the Japanese Society for Food Science and Technology-Nippon Shokuhin Kagaku Kogaku Kaishi, 2000. 47(5): p. 390-393.
455.Li, F.Y., et al., Consumption of hydrogen-rich water protects against ferric nitrilotriacetate-induced nephrotoxicity and early tumor promotional events in rats. Food Chem Toxicol, 2013. 61: p. 248-54.
456.Morita, C., T. Nishida, and K. Ito, Biological toxicity of acid electrolyzed functional water: effect of oral administration on mouse digestive tract and changes in body weight. Arch Oral Biol, 2011. 56(4): p. 359-66.
457.Sakai, T., et al., Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. Vasc Health Risk Manag, 2014. 10: p. 591-7.
458.Tsubone, H., et al., Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative Metabolites in Serum of Thoroughbred Horses. J Equine Sci, 2013. 24(1): p. 1-8.
459.Wang, W.N., et al., [Regulative effects of hydrogen-rich medium on monocytic adhesion and vascular endothelial permeability]. Zhonghua Yi Xue Za Zhi, 2013. 93(43): p. 3467-9.
460.Yahagi, N., et al., Effect of electrolyzed water on wound healing. Artificial Organs, 2000. 24(12): p. 984-987.
461.Zhao, S., et al., Therapeutic effects of hydrogen-rich solution on aplastic anemia in vivo. Cell Physiol Biochem, 2013. 32(3): p. 549-60.
462.Chen, M., et al., Hydrogen-rich water alleviates aluminum-induced inhibition of root elongation in alfalfa via decreasing nitric oxide production. J Hazard Mater, 2014. 267: p. 40-7.
463.Cui, W., et al., Alleviation of cadmium toxicity in Medicago sativa by hydrogen-rich water. Journal of Hazardous Materials, 2013. 260: p. 715-24.
464.Cui, W., et al., Hydrogen-rich water confers plant tolerance to mercury toxicity in alfalfa seedlings. Ecotoxicol Environ Saf, 2014. 105: p. 103-11.
465.Hu, H., et al., Hydrogen-rich water delays postharvest ripening and senescence of kiwifruit. Food Chem, 2014. 156: p. 100-9.
466.Jin, Q., et al., Hydrogen gas acts as a novel bioactive molecule in enhancing plant tolerance to paraquat-induced oxidative stress via the modulation of heme oxygenase-1 signalling system. Plant Cell and Environment, 2013. 36(5): p. 956-69.
467.Lin, Y., et al., Hydrogen-rich water regulates cucumber adventitious root development in a heme oxygenase-1/carbon monoxide-dependent manner. J Plant Physiol, 2014. 171(2): p. 1-8.
468.Maimaiti, J., et al., Isolation and characterization of hydrogen-oxidizing bacteria induced following exposure of soil to hydrogen gas and their impact on plant growth. Environmental Microbiology, 2007. 9(2): p. 435-44.
469.Su, N., et al., Hydrogen-Rich Water Reestablishes ROS Homeostasis but Exerts Differential Effects on Anthocyanin Synthesis in Two Varieties of Radish Sprouts under UV-A Irradiation. J Agric Food Chem, 2014. 62(27): p. 6454-62.
470.Xie, Y., et al., H(2) enhances arabidopsis salt tolerance by manipulating ZAT10/12-mediated antioxidant defence and controlling sodium exclusion. PLoS One, 2012. 7(11): p. e49800.
471.Xie, Y., et al., Reactive Oxygen Species-Dependent Nitric Oxide Production Contributes to Hydrogen-Promoted Stomatal Closure in Arabidopsis. Plant Physiol, 2014. 165(2): p. 759-773.
472.Xu, S., Susong Zhu, Yilong Jiang, Ning Wang, Ren Wang, Wenbiao Shen, and Jie Yang, Hydrogen-rich water alleviates salt stress in rice during seed germination. Plant and Soil, 2013: p. 1-11.
473.Wu, Q., et al., Hydrogen-rich water enhances cadmium tolerance in Chinese cabbage by reducing cadmium uptake and increasing antioxidant capacities. J Plant Physiol, 2015. 175: p. 174-82.
474.Zeng, J., M. Zhang, and X. Sun, Molecular hydrogen is involved in phytohormone signaling and stress responses in plants. PLoS One, 2013. 8(8): p. e71038.
475.Zhang, X., et al., Protective effects of hydrogen-rich water on the photosynthetic apparatus of maize seedlings (Zea mays L.) as a result of an increase in antioxidant enzyme activities under high light stress. Plant Growth Regulation,
Assenza di effetti collaterali:
476.Jung, H.S., et al., Evaluate of Electrochemical Characteristics in Electrolyzed Reduced Water. Korean J. Microscopy, 2008. 38(4): p. 321-324.
477.Kayar, S.R., E.C. Parker, and A.L. Harbin, Metabolism and thermoregulation in guinea pigs in hyperbaric hydrogen: Effects of pressure. Journal of Thermal Biology, 1997. 22(1): p. 31-41.
478.Lee, K.J., et al., The immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice. Biol Pharm Bull, 2009. 32(3): p. 456-62.
479.Merne, M.E., K.J. Syrjanen, and S.M. Syrjanen, Systemic and local effects of long-term exposure to alkaline drinking water in rats. Int J Exp Pathol, 2001. 82(4): p. 213-9.
480.Ni, X.X., et al., Protective effect of hydrogen-rich saline on decompression sickness in rats. Aviation Space and Environmental Medicine, 2011. 82(6): p. 604-9.
481.Saitoh, Y., et al., Biological safety of neutral-pH hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity and subchronic oral toxicity. Toxicology and Industrial Health, 2010. 26(4): p. 203-216.
482.Sumiyoshi, K., Abstracts from the Functional Water Symposium ‘96 Held at Fukuoka Prefecture, Japan, November 28 and 29, 1996. Artificial Organs, 1997. 21: p. 1222-1226.
483.Unknown, Navy Studies Hydrogen as Breathing Gas. Design News, 1973. 28(15): p. 22-22.
484.Watanabe, T., Y. Kishikawa, and W. Shirai, Influence of alkaline ionized water on rat erythrocyte hexokinase activity and myocardium. J Toxicol Sci, 1997. 22(2): p. 141-52.
485.Watanabe, T. and Y. Kishikawa, Degradation of myocardiac myosin and creatine kinase in rats given alkaline ionized water. J Vet Med Sci, 1998. 60(2): p. 245-50.
486.Watanabe, T., et al., Influences of alkaline ionized water on milk yield, body weight of offspring and perinatal dam in rats. J Toxicol Sci, 1998. 23(5): p. 365-71.
487.Watanabe, T., et al., Histopathological influence of alkaline ionized water on myocardial muscle of mother rats. J Toxicol Sci, 1998. 23(5): p. 411-7.
488.Watanabe, T., et al., Influences of alkaline ionized water on milk electrolyte concentrations in maternal rats. J Toxicol Sci, 2000. 25(5): p. 417-22.
489.Yoon, Y.S., et al., The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice. Food and Chemical Toxicology, 2011. 49(8): p. 1814-9.
490.Yamagishi, Y., et al., Hepatotoxicity of sub-nanosized platinum particles in mice. Pharmazie, 2013. 68(3): p. 178-82.
491.Yamagishi, Y., et al., Acute and chronic nephrotoxicity of platinum nanoparticles in mice. Nanoscale Res Lett, 2013. 8(11
CLICCA QUI PER LA TERZA PARTE